Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease.

ABSTRACT:

Objectives

To assess the neurobiological substrate of initial cognitive decline in Parkinson's disease (PD) to inform patient management, clinical trial design, and development of treatments.

Methods

We longitudinally assessed, up to 3 years, 423 newly diagnosed patients with idiopathic PD, untreated at baseline, from 33 international movement disorder centers. Study outcomes were four determinations of cognitive impairment or decline, and biomarker predictors were baseline dopamine transporter (DAT) single photon emission computed tomography (SPECT) scan, structural magnetic resonance imaging (MRI; volume and thickness), diffusion tensor imaging (mean diffusivity and fractional anisotropy), cerebrospinal fluid (CSF; amyloid beta [Aβ], tau and alpha synuclein), and 11 single

SUBMITTER: Caspell-Garcia C 

PROVIDER: S-EPMC5435130 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature