Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population.

ABSTRACT: EEG alpha activity is the dominant oscillation in most adult humans, is highly heritable, and has been associated with a number of cognitive functions. Two EEG phenotypes, low- and high-voltage alpha (LVA & HVA), have been demonstrated to have high heritabilities. They have different prevalence depending on a population's ancestral origins. In the present study we assessed the influence of ancestry admixture on EEG alpha power, and conducted a whole genome sequencing association analysis and an ancestry-informed polygenic study on those phenotypes in a Native American (NA) population that has a high prevalence of LVA. Seven common variants, in LD with each other upstream from gene ASIC2, reached genome-wide significance (p = 2 × 10^-8 ) having a positive association with alpha vo

SUBMITTER: Peng Q 

PROVIDER: S-EPMC5435561 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature