HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.

ABSTRACT: Chordomas are rare tumours of the bone arising along the spine from clivus to sacrum. We compared three chordoma cell lines of the clivus region including the newly established clivus chordoma cell line, U-CH14, with nine chordoma cell lines originating from sacral primaries by morphology, on genomic and expression levels and with patient samples from our chordoma tissue bank. Clinically, chordomas of the clivus were generally smaller in size at presentation and patients with sacral chordomas had more metastases and more often recurrent disease. All chordoma cell lines had a typical physaliphorous morphology and expressed brachyury, S100-protein and cytokeratin. By expression analyses we detected differentially expressed genes in the clivus derived cell lines as compared to the sacral cell

SUBMITTER: Jager D 

PROVIDER: S-EPMC5435709 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature