Ontology highlight
ABSTRACT:
SUBMITTER: Onderak AM
PROVIDER: S-EPMC5435864 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20170328 6
RNA surveillance via the nuclear exosome requires cofactors such as the helicase SKIV2L2 to process and degrade certain noncoding RNAs. This research aimed to characterize the phenotype associated with RNAi knockdown of <i>Skiv2l2</i> in two murine cancer cell lines: Neuro2A and P19. SKIV2L2 depletion in Neuro2A and P19 cells induced changes in gene expression indicative of cell differentiation and reduced cellular proliferation by 30%. Propidium iodide-based cell-cycle analysis of <i>Skiv2l2</i ...[more]