Structural explanation of poor prognosis of amyotrophic lateral sclerosis in the non-demented state.

ABSTRACT:

Background and purpose

Amyotrophic lateral sclerosis (ALS), a motor neuron disease, is associated with various cortical symptoms including mild cognitive decline with behavior changes, suggesting the involvement of extra-motor areas in ALS. Our aim was to investigate the specific patterns of brain atrophy in sporadic, impaired ALS patients without commonly known genetic mutations using voxel-based morphometry.

Materials and methods

Forty-seven patients with sporadic ALS and 28 age-matched healthy controls were recruited. ALS participants were divided into three groups according to comprehensive neuropsychological testing: pure (ALS-pure), cognitive impairment (ALSci) and behavioral impairment (ALSbi). Quantitative comparison of brain atrophy patterns was performed amongst th

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC5436047 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature