Resting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis.

ABSTRACT:

Introduction

We performed a systematic review and meta-analysis of the Alzheimer's disease (AD) literature to examine consistency of functional connectivity alterations in AD dementia and mild cognitive impairment, using resting-state functional magnetic resonance imaging.

Methods

Studies were screened using a standardized procedure. Multiresolution statistics were performed to assess the spatial consistency of findings across studies.

Results

Thirty-four studies were included (1363 participants, average 40 per study). Consistent alterations in connectivity were found in the default mode, salience, and limbic networks in patients with AD dementia, mild cognitive impairment, or in both groups. We also identified a strong tendency in the literature toward specific exami

SUBMITTER: Badhwar A 

PROVIDER: S-EPMC5436069 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature