Foxp3⁺ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis.

ABSTRACT: Foxp3⁺ regulatory T cells (Treg cells) modulate the immune system and maintain self-tolerance, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution after transplantation is unclear. Here we show that B-cell lymphopoiesis is impaired in Treg-depleted mice, yet this reduced B-cell lymphopoiesis is rescued by adoptive transfer of affected HSCs or bone marrow cells into Treg-competent recipients. B-cell reconstitution is abrogated in both syngeneic and allogeneic transplantation using Treg-depleted mice as recipients. Treg cells can control physiological IL-7 production that is indispensable for normal B-cell lymphopoiesis and is mainly sustained by a subpopulation of ICAM1⁺ perivascular stromal cells. Our study demonstrates tha

SUBMITTER: Pierini A 

PROVIDER: S-EPMC5436085 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature