The role of sex and body weight on the metabolic effects of high-fat diet in C57BL/6N mice.

ABSTRACT:

Background

Metabolic disorders are commonly investigated using knockout and transgenic mouse models on the C57BL/6N genetic background due to its genetic susceptibility to the deleterious metabolic effects of high-fat diet (HFD). There is growing awareness of the need to consider sex in disease progression, but limited attention has been paid to sexual dimorphism in mouse models and its impact in metabolic phenotypes. We assessed the effect of HFD and the impact of sex on metabolic variables in this strain.

Methods

We generated a reference data set encompassing glucose tolerance, body composition and plasma chemistry data from 586 C57BL/6N mice fed a standard chow and 733 fed a HFD collected as part of a high-throughput phenotyping pipeline. Linear mixed model regression ana

SUBMITTER: Ingvorsen C 

PROVIDER: S-EPMC5436097 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature