Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates.

ABSTRACT: The neuropeptides oxytocin (OXT) and vasopressin (AVP) have been identified as modulators of emotional social behaviors and associated with neuropsychiatric disorders characterized by social dysfunction. Experimental and therapeutic use of OXT and AVP via the intranasal route is the subject of extensive clinical research. However, the large-scale functional substrates directly engaged by these peptides and their functional dynamics remain elusive. By using cerebral blood volume (CBV) weighted fMRI in the mouse, we show that intranasal administration of OXT rapidly elicits the transient activation of cortical regions and a sustained activation of hippocampal and forebrain areas characterized by high oxytocin receptor density. By contrast, intranasal administration of AVP produced a robust a

SUBMITTER: Galbusera A 

PROVIDER: S-EPMC5436116 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature