Ontology highlight
ABSTRACT:
SUBMITTER: Contrepois K
PROVIDER: S-EPMC5436145 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nature communications 20170510
The senescence of mammalian cells is characterized by a proliferative arrest in response to stress and the expression of an inflammatory phenotype. Here we show that histone H2A.J, a poorly studied H2A variant found only in mammals, accumulates in human fibroblasts in senescence with persistent DNA damage. H2A.J also accumulates in mice with aging in a tissue-specific manner and in human skin. Knock-down of H2A.J inhibits the expression of inflammatory genes that contribute to the senescent-asso ...[more]