A Novel Method to Identify Differential Pathways in Hippocampus Alzheimer's Disease.

ABSTRACT: BACKGROUND Alzheimer's disease (AD) is the most common type of dementia. The objective of this paper is to propose a novel method to identify differential pathways in hippocampus AD. MATERIAL AND METHODS We proposed a combined method by merging existed methods. Firstly, pathways were identified by four known methods (DAVID, the neaGUI package, the pathway-based co-expressed method, and the pathway network approach), and differential pathways were evaluated through setting weight thresholds. Subsequently, we combined all pathways by a rank-based algorithm and called the method the combined method. Finally, common differential pathways across two or more of five methods were selected. RESULTS Pathways obtained from different methods were also different. The combined method obtained 1639 path

SUBMITTER: Liu CH 

PROVIDER: S-EPMC5436445 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature