Transcriptome analysis for the identification of cellular markers related to trabecular meshwork differentiation.

ABSTRACT:

Background

Development of primary open-angle glaucoma (POAG) is associated with the malfunctioning trabecular meshwork (TM). Cell therapy offers great potential for the treatment of POAG, but requires the generation of functional TM cells in vitro to replace the lost/dysfunctional cells. TM differentiation in vitro from various stem cell types must be monitored by the expression of specific markers. However, no single definitive marker of the TM has been identified.

Results

To identify robust markers of TM differentiation, we performed global transcriptome profiling using high-density oligonucleotide microarray on ex vivo TM tissue and cultured TM progenitors. Corneal and scleral tissues were also used in the analysis. After removal of genes expressed in the cornea and scler

SUBMITTER: Sathiyanathan P 

PROVIDER: S-EPMC5436446 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature