Radiosensitization effect of hsa-miR-138-2-3p on human laryngeal cancer stem cells.

ABSTRACT:

Background

Treatments that target cancer stem cells play an important role in the controlling and eliminating of tumor initiation as well as in development, progression, and chemotherapy/radiotherapy resistance. In our previous study, we cultured and harvested human laryngeal cancer stem cells (CSCs) and applied microRNA biochips to screen differentially expressed miRNAs that were related to radiation tolerance in irradiated human laryngeal CSCs. According to the predicted genes and pathways of differential miRNAs target, down-regulated expression of hsa-miR-138-2-3p under radiation was thought to play a key role in enhancing the radio-sensitivity in human laryngeal squamous cancer stem cells.

Method

To investigate the radiational enhancement of hsa-miR-138-2-3p, we transfec

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC5436573 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature