The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.

ABSTRACT: Four possible isomers of essramycin, a natural product from a marine Streptomyces species isolated from the Egyptian Mediterranean coast, were synthesized. The structures for the isomers were assigned unequivocally by (1)H NMR, (13)C NMR, high-resolution mass spectrometry, and X-ray crystal structure determinations. Notwithstanding the earlier report of broad-spectrum antibacterial activity for the natural product, none of the four isomers exhibited any such activity.

SUBMITTER: Wang H 

PROVIDER: S-EPMC5436578 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature