CorNet: Assigning function to networks of co-evolving residues by automated literature mining.

ABSTRACT: CorNet is a web-based tool for the analysis of co-evolving residue positions in protein super-family sequence alignments. CorNet projects external information such as mutation data extracted from literature on interactively displayed groups of co-evolving residue positions to shed light on the functions associated with these groups and the residues in them. We used CorNet to analyse six enzyme super-families and found that groups of strongly co-evolving residues tend to consist of residues involved in a same function such as activity, specificity, co-factor binding, or enantioselectivity. This finding allows to assign a function to residues for which no data is available yet in the literature. A mutant library was designed to mutate residues observed in a group of co-evolving residues pred

SUBMITTER: van den Bergh T 

PROVIDER: S-EPMC5436653 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature