N-terminal pro-B-type natriuretic peptide in amniotic fluid of fetuses with known or suspected cardiac load.

ABSTRACT:

Background

Myocardial dysfunction occurs in a variety of fetal disorders. Findings from adult cardiology, where n-terminal pro-B-type natriuretic peptide (nt-proBNP) is an established biomarker of left ventricular dysfunction have been extended to fetal life. Since fetal blood sampling is technically challenging we investigated amniotic fluid nt-proBNP for its suitability to diagnose fetal myocardial dysfunction.

Methods

Ultrasound, Doppler examination and echocardiography was applied to classify cases and controls. Amniotic fluid nt-proBNP to amniotic fluid total protein ratio was calculated and compared to the gestational age-dependent reference intervals. In a subset of cases, fetal and maternal plasma nt-proBNP levels were determined.

Results

Specimen from 391 fet

SUBMITTER: Leufgen C 

PROVIDER: S-EPMC5436674 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature