Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor.

ABSTRACT:

Aims

The endothelium has emerged recently as a therapeutic target in the treatment of hypertension because endothelial dysfunction and subsequent vascular rarefaction cause target organ damage and further elevate blood pressure (BP). It led us to hypothesize that one of the endothelial survival factors, a potent derivative of angiopoietin-1 (cartilage oligomeric matrix protein, COMP-Ang-1), could be a novel class of antihypertensive agents that maintain endothelial integrity and function, thereby preventing the development of hypertension and target organ damage.

Methods and results

To study the role of COMP-Ang-1 in preventing hypertension and target organ damage, a COMP-Ang-1 plasmid was electroporated into adductor muscles of 6 weeks old, pre-hypertensive, spontaneously h

SUBMITTER: Lee JS 

PROVIDER: S-EPMC5436684 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature