Effect of Helicobacter pylori infection on the link between GLP-1 expression and motility of the gastrointestinal tract.

ABSTRACT:

Background

Although Helicobacter pylori (H. pylori) infection is closely associated with the development of peptic ulcer, its involvement in pathophysiology in the lower intestinal tract and gastrointestinal (GI) motility remains unclear. Glucagon-like peptide-1 (GLP-1) is a gut hormone produced in the lower intestinal tract and involved in GI motility. Here, we investigated the effect of H. pylori infection on the link between GLP-1 expression and motility of the GI tract.

Methods

C57BL/6 mice were inoculated with a H. pylori strain. Twelve weeks later, the H. pylori-infected mice underwent H. pylori eradication treatment. GI tissues were obtained from the mice at various time intervals, and evaluated for the severity of gastric inflammatory cell infiltration and immunohist

SUBMITTER: Eda H 

PROVIDER: S-EPMC5436696 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature