The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review.

ABSTRACT:

Background

Colorectal cancer is one of the most common cancers worldwide, and is influenced by the interplay of various factors, including a very strong genetic component. For instance, incorrect mitochondrial biogenesis is correlated with increased risk of developing colorectal cancer. Thus, it is important to understand the consequences of changes in both the expression and the correct function of the transcription factors that regulate mitochondrial biogenesis, namely NRF2.

Objectives

The main objective of this paper is to characterise the relationship between NRF2 and colorectal cancer by compiling data from an exhaustive literature search.

Methods

Information was obtained by defining specific search terms and searching in several databases. After a strict selecti

SUBMITTER: Gonzalez-Donquiles C 

PROVIDER: S-EPMC5436741 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature