ROS regulation of axonal mitochondrial transport is mediated by Ca2+ and JNK in Drosophila.

ABSTRACT: Mitochondria perform critical functions including aerobic ATP production and calcium (Ca2+) homeostasis, but are also a major source of reactive oxygen species (ROS) production. To maintain cellular function and survival in neurons, mitochondria are transported along axons, and accumulate in regions with high demand for their functions. Oxidative stress and abnormal mitochondrial axonal transport are associated with neurodegenerative disorders. However, we know little about the connection between these two. Using the Drosophila third instar larval nervous system as the in vivo model, we found that ROS inhibited mitochondrial axonal transport more specifically, primarily due to reduced flux and velocity, but did not affect transport of other organelles. To understand the mechanisms underlyi

SUBMITTER: Liao PC 

PROVIDER: S-EPMC5436889 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature