Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.

ABSTRACT: Rhomboid family protein RHBDF2, an upstream regulator of the epidermal growth factor (EGF) receptor signaling, has been implicated in cutaneous wound healing. However, the underlying molecular mechanisms are still emerging. In humans, a gain-of-function mutation in the RHBDF2 gene accelerates cutaneous wound healing in an EGFR-dependent manner. Likewise, a gain-of-function mutation in the mouse Rhbdf2 gene (Rhbdf2^cub/cub) shows a regenerative phenotype (rapid ear-hole closure) resulting from constitutive activation of the EGFR pathway. Because the RHBDF2-regulated EGFR pathway is relevant to cutaneous wound healing in humans, we used Rhbdf2^cub/cub mice to investigate the biological networks and pathways leading to accelerated ear-hole closure, with the goal of identif

SUBMITTER: Hosur V 

PROVIDER: S-EPMC5436942 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature