Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb.

ABSTRACT: Age-related decline in olfactory function affects the quality of life in elderly people and also potentially represents an early clinical symptom of neurodegenerative disorder. Olfactory bulb (OB) plays a central role in olfactory information transmitting and signal processing. The mechanisms underlying this impairment remain unclear. In the current study, microarray was used to investigate differentially expressed protein coding genes (PCGs) and long non-coding RNAs (lncRNAs) in OBs from three groups of mice of different ages (2 months-old young adults, 6 months-old mature adults and 20 months-old aged adults), for their potential roles in olfactory impairment. Gene Ontology and pathway analysis results showed that the differentially expressed PCGs in the OBs from aged mice were mainly as

SUBMITTER: Wang M 

PROVIDER: S-EPMC5437011 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature