The Role of Co-chaperones in Synaptic Proteostasis and Neurodegenerative Disease.

ABSTRACT: Synapses must be preserved throughout an organism's lifespan to allow for normal brain function and behavior. Synapse maintenance is challenging given the long distances between the termini and the cell body, reliance on axonal transport for delivery of newly synthesized presynaptic proteins, and high rates of synaptic vesicle exo- and endocytosis. Hence, synapses rely on efficient proteostasis mechanisms to preserve their structure and function. To this end, the synaptic compartment has specific chaperones to support its functions. Without proper synaptic chaperone activity, local proteostasis imbalances lead to neurotransmission deficits, dismantling of synapses, and neurodegeneration. In this review, we address the roles of four synaptic chaperones in the maintenance of the nerve termin

SUBMITTER: Gorenberg EL 

PROVIDER: S-EPMC5437171 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature