The clinical application of angiostatic therapy in combination with radiotherapy: past, present, future.

ABSTRACT: Although monotherapy with angiostatic drugs is still far from effective, there is abundant evidence that angiostatic therapy can improve the efficacy of conventional treatments like radiotherapy. This has instigated numerous efforts to optimize and clinically implement the combination of angiostatic drugs with radiation treatment. The results from past and present clinical trials that explored this combination therapy indeed show encouraging results. However, current findings also show that the combination has variable efficacy and is associated with increased toxicity. This indicates that combining radiotherapy with angiostatic drugs not only holds opportunities but also provides several challenges. In the current review, we provide an update of the most recent insights from clinical tria

SUBMITTER: Hamming LC 

PROVIDER: S-EPMC5437175 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature