Pharmacological effects of asiatic acid in glioblastoma cells under hypoxia.

ABSTRACT: Glioblastoma multiforme is the most common and malignant primary brain tumor in adults. Despite current treatment options including surgery followed by radiation and chemotherapy with temozolomide and cisplatin, the median survival rate remains low (<16 months). Combined with increasing drug resistance and the inability of some compounds to cross the blood-brain barrier, novel compounds are being sought for the treatment of this disease. Here, we aimed to examine the pharmacological effect of Asiatic acid (AA) in glioblastoma under hypoxia. To investigate the effects of AA on cell viability, proliferation, apoptosis, and wound healing, SVG p12 fetal glia and U87-MG grade IV glioblastoma cells were cultured under normoxic (21% O₂) and hypoxic (1% O₂) conditions. In nor

SUBMITTER: Thakor FK 

PROVIDER: S-EPMC5437181 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature