Oral branched-chain amino acid granules improve structure and function of human serum albumin in cirrhotic patients.

ABSTRACT:

Background and aims

The aim of this study was to evaluate structural and functional alterations of human serum albumin (HSA), with a special focus on the oxidized and reduced forms, in patients with chronic liver disease. We also investigated whether oral branched-chain amino acid (BCAA) supplementation could induce structural changes and improve the functions of HSA.

Methods

The proportion of reduced and oxidized HSA was determined in 16 healthy controls and in 20 chronic hepatitis and 100 cirrhotic patients with stable conditions. To evaluate the functional properties of HSA, this study focused on the antioxidant and binding functions. The radical scavenging activity and binding ability of purified HSA were measured in 68 participants. After BCAA administration for 6 month

SUBMITTER: Setoyama H 

PROVIDER: S-EPMC5437197 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature