Effect of cranial irradiation on sperm concentration of adult survivors of childhood acute lymphoblastic leukemia: a report from the St. Jude Lifetime Cohort Study†.

ABSTRACT:

Study question

Does lower dose (<26 Gy) cranial radiation therapy (CRT) used for central nervous system prophylaxis in acute lymphoblastic leukemia (ALL) adversely affect sperm concentration or morphology?

Summary answer

CRT doses <26 Gy had no demonstrable adverse effect on sperm concentration or morphology.

What is known already

Treatment with alkylating agents produces oligospermia and azoospermia in some patients. No prior study has been large enough to evaluate the independent effects of alkylating agents and lower dose (<26 Gy) CRT on sperm concentration or morphology.

Study design, size, duration

This cross-sectional study included male adult survivors of pediatric ALL who had received alkylating agent chemotherapy with or without CRT and who enrolled in

SUBMITTER: Green DM 

PROVIDER: S-EPMC5437362 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature