Restitution slope is principally determined by steady-state action potential duration.

ABSTRACT:

Aims

The steepness of the action potential duration (APD) restitution curve and local tissue refractoriness are both thought to play important roles in arrhythmogenesis. Despite this, there has been little recognition of the apparent association between steady-state APD and the slope of the restitution curve. The objective of this study was to test the hypothesis that restitution slope is determined by APD and to examine the relationship between restitution slope, refractoriness and susceptibility to VF.

Methods and results

Experiments were conducted in isolated hearts and ventricular myocytes from adult guinea pigs and rabbits. Restitution curves were measured under control conditions and following intervention to prolong (clofilium, veratridine, bretylium, low [Ca]e, chron

SUBMITTER: Shattock MJ 

PROVIDER: S-EPMC5437364 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature