Genomic landscape of extended-spectrum β-lactamase resistance in Escherichia coli from an urban African setting.

ABSTRACT:

Objectives

Efforts to treat Escherichia coli infections are increasingly being compromised by the rapid, global spread of antimicrobial resistance (AMR). Whilst AMR in E. coli has been extensively investigated in resource-rich settings, in sub-Saharan Africa molecular patterns of AMR are not well described. In this study, we have begun to explore the population structure and molecular determinants of AMR amongst E. coli isolates from Malawi.

Methods

Ninety-four E. coli isolates from patients admitted to Queen's Hospital, Malawi, were whole-genome sequenced. The isolates were selected on the basis of diversity of phenotypic resistance profiles and clinical source of isolation (blood, CSF and rectal swab). Sequence data were analysed using comparative genomics and phylogenetic

SUBMITTER: Musicha P 

PROVIDER: S-EPMC5437524 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature