Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle.

ABSTRACT: Single nucleotide polymorphism (SNP) arrays for domestic cattle have catalyzed the identification of genetic markers associated with complex traits for inclusion in modern breeding and selection programs. Using actual and imputed Illumina 778K genotypes for 3887 U.S. beef cattle from 3 populations (Angus, Hereford, SimAngus), we performed genome-wide association analyses for feed efficiency and growth traits including average daily gain (ADG), dry matter intake (DMI), mid-test metabolic weight (MMWT), and residual feed intake (RFI), with marker-based heritability estimates produced for all traits and populations.Moderate and/or large-effect QTL were detected for all traits in all populations, as jointly defined by the estimated proportion of variance explained (PVE) by marker effects (PVE???1.0%) and a nominal P-value threshold (P???5e-05). Lead SNPs with PVE???2.0% were considered putative evidence of large-effect QTL (n?=?52), whereas those with PVE???1.0% but?

SUBMITTER: Seabury CM 

PROVIDER: S-EPMC5437562 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature