Association of 4p14 and 6q27 variation with Graves disease: a case-control study and a meta-analysis of available evidence.

ABSTRACT:

Background

The etiology of the Graves' disease (GD) is largely unknown. However, genetic factors are believed to play a major role. A recent genome-wide association study in a Han Chinese sample collection revealed two new Graves' disease (GD) risk loci within chromosome band 4p14 and 6q27. In this study, we aimed to investigate these associations with Weifang Han Chinese population of Shandong province and perform a meta-analysis of associations with GD.

Methods

A case-control study was conducted to investigate association of variation within 4p14 and 6q27 to GD susceptibility in Weifang Han Chinese population of Shandong province. SNP rs6832151 at chromosome 4p14 and SNP rs9355610 at chromosome 6q27 was selected for genotyping in 2,382 GD patients and 3,092 unrelated contr

SUBMITTER: Li FM 

PROVIDER: S-EPMC5437675 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature