Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation.

ABSTRACT: We recently demonstrated that desipramine reduces the sleep-related loss of upper airway dilator muscle activity and reduces pharyngeal collapsibility in healthy humans without obstructive sleep apnoea (OSA). The aim of the present physiological study was to determine the effects of desipramine on upper airway collapsibility and apnoea-hypopnea index (AHI) in OSA patients.A placebo-controlled, double-blind, randomised crossover trial in 14 OSA patients was performed. Participants received treatment or placebo in randomised order before sleep. Pharyngeal collapsibility (critical collapsing pressure of the upper airway (P_crit)) and ventilation under both passive (V'_0,passive) and active (V'_0,active) upper airway muscle conditions were evaluated with continuou

SUBMITTER: Taranto-Montemurro L 

PROVIDER: S-EPMC5437721 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature