Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish.

ABSTRACT: Satellite cells, also known as muscle stem cells, are responsible for skeletal muscle growth and repair in mammals. Pax7 and Pax3 transcription factors are established satellite cell markers required for muscle development and regeneration, and there is great interest in identifying additional factors that regulate satellite cell proliferation, differentiation, and/or skeletal muscle regeneration. Due to the powerful regenerative capacity of many zebrafish tissues, even in adults, we are exploring the regenerative potential of adult zebrafish skeletal muscle. Here, we show that adult zebrafish skeletal muscle contains cells similar to mammalian satellite cells. Adult zebrafish satellite-like cells have dense heterochromatin, express Pax7 and Pax3, proliferate in response to injury, and sho

SUBMITTER: Berberoglu MA 

PROVIDER: S-EPMC5437870 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature