Genetic and Modeling Approaches Reveal Distinct Components of Impulsive Behavior.

ABSTRACT: Impulsivity is an endophenotype found in many psychiatric disorders including substance use disorders, pathological gambling, and attention deficit hyperactivity disorder. Two behavioral features often considered in impulsive behavior are behavioral inhibition (impulsive action) and delayed gratification (impulsive choice). However, the extent to which these behavioral constructs represent distinct facets of behavior with discrete biological bases is unclear. To test the hypothesis that impulsive action and impulsive choice represent statistically independent behavioral constructs in mice, we collected behavioral measures of impulsivity in a single cohort of mice using well-validated operant behavioral paradigms. Mice with manipulation of serotonin 1B receptor (5-HT_1BR) expressi

SUBMITTER: Nautiyal KM 

PROVIDER: S-EPMC5437890 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature