Coffee consumption is associated with DNA methylation levels of human blood.

ABSTRACT: Beneficial health effects have been attributed to coffee consumption, but it is not yet known whether epigenetics may have a role in this process. Here we associate epigenome-wide DNA methylation levels to habitual coffee consumption from two studies with blood (2100 and 215 participants), and one with saliva samples (256 participants). Adjusting for age, gender, and blood cell composition, one CpG (cg21566642 near ALPPL2) surpassed genome-wide significance (P=3.7 × 10^-10) and from among 10 additional CpGs significant at P≤5.0 × 10^-6, six were located within 1500 bps of a transcriptional start site. Results for these 11 top-ranked CpGs remained significant after further adjusting for smoking. Also, methylation levels of another 135 CpGs were influenced by both coffee

SUBMITTER: Chuang YH 

PROVIDER: S-EPMC5437893 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature