Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons.

ABSTRACT:

Importance

Schizophrenia candidate genes participate in common molecular pathways that are regulated by activity-dependent changes in neurons. One important next step is to further our understanding on the role of activity-dependent changes of gene expression in the etiopathogenesis of schizophrenia.

Objective

To examine whether neuronal activity-dependent changes of gene expression are dysregulated in schizophrenia.

Design, setting, and participants

Neurons differentiated from human-induced pluripotent stem cells derived from 4 individuals with schizophrenia and 4 unaffected control individuals were depolarized using potassium chloride. RNA was extracted followed by genome-wide profiling of the transcriptome. Neurons were planted on June 21, 2013, and harvested on Au

SUBMITTER: Roussos P 

PROVIDER: S-EPMC5437975 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature