Regulation of dopaminergic function: an [¹⁸F]-DOPA PET apomorphine challenge study in humans.

ABSTRACT: Dopaminergic function has a key role in normal brain function, dopaminergic dysfunction being implicated in numerous neuropsychiatric disorders. Animal studies show that dopaminergic stimulation regulates dopaminergic function, but it is not known whether this exists in humans. In the first study (study 1), we measured dopamine synthesis capacity (indexed as K_i^cer) to identify the relationship between baseline and change in K_i^cer under resting conditions for comparison with effects of dopaminergic stimulation. In the second study (study 2), we used a within-subjects design to test effects of dopaminergic stimulation on dopamine synthesis capacity. In study 1, eight volunteers received two ¹⁸F-DOPA scans on separate days, both at rest.

SUBMITTER: Jauhar S 

PROVIDER: S-EPMC5438020 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature