BDNF val66met association with serotonin transporter binding in healthy humans.

ABSTRACT: The serotonin transporter (5-HTT) is a key feature of the serotonin system, which is involved in behavior, cognition and personality and implicated in neuropsychiatric illnesses including depression. The brain-derived neurotrophic factor (BDNF) val66met and 5-HTTLPR polymorphisms have predicted differences in 5-HTT levels in humans but with equivocal results, possibly due to limited sample sizes. Within the current study we evaluated these genetic predictors of 5-HTT binding with [¹¹C]DASB positron emission tomography (PET) in a comparatively large cohort of 144 healthy individuals. We used a latent variable model to determine genetic effects on a latent variable (5-HTT_LV), reflecting shared correlation across regional 5-HTT binding (amygdala, caudate, hippocampus, mi

SUBMITTER: Fisher PM 

PROVIDER: S-EPMC5438027 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature