Transcriptomic analyses and leukocyte telomere length measurement in subjects exposed to severe recent stressful life events.

ABSTRACT: Stressful life events occurring in adulthood have been found able to affect mood and behavior, thus increasing the vulnerability for several stress-related psychiatric disorders. However, although there is plenty of clinical data supporting an association between stressful life events in adulthood and an enhanced vulnerability for psychopathology, the underlying molecular mechanisms are still poorly investigated. Thus, in this study we performed peripheral/whole-genome transcriptomic analyses in blood samples obtained from 53 adult subjects characterized for recent stressful life events occurred within the previous 6 months. Transcriptomic data were analyzed using Partek Genomics Suite; pathway and network analyses were performed using Ingenuity Pathway Analysis and GeneMANIA Software. We

SUBMITTER: Lopizzo N 

PROVIDER: S-EPMC5438034 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature