Improvements in antenatal screening for Down's syndrome.

ABSTRACT:

Objectives

To estimate improvements to four antenatal screening tests for Down's syndrome (first trimester Combined, second trimester Quadruple, and first and second trimester Integrated and Serum Integrated tests) based on adding ductus venosus pulsatility index (DVPI), fetal nasal bone examination (NBE) and serum placental growth factor (PlGF).

Setting

Statistical analysis of data from several sources modelled using the maternal age distribution of live births in England and Wales from 2006 to 2008.

Methods

Monte Carlo simulation carried out to estimate the screening performance of tests with the addition of combinations of DVPI, NBE and PlGF.

Results

At a 95% detection rate (DR), with first trimester markers measured at 11 completed weeks' gestation, the add

SUBMITTER: Wald NJ 

PROVIDER: S-EPMC5438079 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature