AChiralPentagonalPolyhedralFramework forCharacterizingVirusCapsidStructures.

ABSTRACT: Recent developments of rational strategies for the design of antiviral therapies, including monoclonal antibodies (mAbs), have naturally relied extensively on available viral structural information. As new strategies continue to be developed, it is equally important to continue to refine our understanding and interpretation of viral structural data. There are known limitations to the traditional (Caspar-Klug) theory for describing virus capsid structures that involves subdividing a capsid into triangular subunits. In this context, we describe a more general polyhedral framework for describing virus capsid structures that is able to account for many of these limitations, including a more thorough characterization of intersubunit interfaces. Additionally, our use of pentagonal subunits inste

SUBMITTER: Raguram A 

PROVIDER: S-EPMC5438269 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature