Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample.

ABSTRACT:

Introduction

Whether co-occurring neuropathologies interact or independently affect clinical disease progression is uncertain. We estimated rates of clinical progression and tested whether associations between clinical progression and Alzheimer's disease neuropathology (ADNP) were modified by co-occurring Lewy body disease (LBD) or vascular brain injury (VBI).

Methods

Linear mixed effects models evaluated longitudinal trends in the Clinical Dementia Rating Scale Sum of Boxes on 2046 autopsied participants seen at a U.S. Alzheimer's Disease Center.

Results

Annual clinical progression was slightly faster for ADNP + LBD compared with ADNP only (P = .06) and slightly slower for ADNP + VBI (P = .003). Differences in progression were less than expected if each neuropatholog

SUBMITTER: Brenowitz WD 

PROVIDER: S-EPMC5438283 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature