Prognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors.

ABSTRACT: Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified the differential expression of proteins between insulinoma and their paired tissues by proteomic analysis, and evaluated the prognostic significance of specific proteins in pancreatic neuroendocrine tumors including insulinoma. The differential expression of select proteins was validated in more than 300 tumors using immunohistochemical staining and western blot. Methylation of UCH-L1 promoter in tumors was examined by methylation specific PCR and validated by sequencing. The concurrent expression of UCH-L1 and α-internexin was correlated with the prognosis in 2 independent collectives of patients with tumors. Sixty-two and 219 proteins were signi

SUBMITTER: Song YL 

PROVIDER: S-EPMC5438410 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature