Phase IIb Study of Intranasal Glutathione in Parkinson's Disease.

ABSTRACT:

Background

Reduced glutathione (GSH) is an endogenously synthesized tripeptide depleted early in the course of Parkinson's disease (PD) and GSH augmentation has been proposed as a therapeutic strategy in PD.

Objective

This Phase IIb study was designed to evaluate whether a Phase III study of intranasal GSH, (in)GSH, for symptomatic relief is warranted and to determine the most appropriate trial design for a disease-modification study.

Methods

This was a double-blind, placebo-controlled trial of 45 individuals with Hoehn & Yahr Stage 1-3 PD. Participants were randomized to receive intranasal placebo (saline), 100 mg GSH, or 200 mg GSH thrice daily for three months, and were observed over a one-month washout period.

Results

All cohorts improved over the intervent

SUBMITTER: Mischley LK 

PROVIDER: S-EPMC5438472 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature