Association of fibrinogen level with early neurological deterioration among acute ischemic stroke patients with diabetes.

ABSTRACT:

Background

Diabetes mellitus (DM) is a risk factor for early neurological deterioration (END) in acute ischemic stroke. The prothrombotic protein fibrinogen is frequently elevated in patients with diabetes, and may be associated with poorer prognoses. We evaluated whether fibrinogen is associated with END in patients with diabetes after acute ischemic stroke.

Methods

We included 3814 patients from a single hospital database admitted within 72 h of onset of ischemic stroke. END was defined as an increase in the National Institutes of Health Stroke Scale (NIHSS) ≥2 within 7 days post-admission. In the total population (END, n = 661; non-END, n = 3153), univariate and multivariate analyses were performed to assess fibrinogen as an independent predictor for END. We then performe

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC5438529 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature