Notch ligand Delta-like 1 as a novel molecular target in childhood neuroblastoma.

ABSTRACT:

Background

Neuroblastoma is the most common extracranial solid malignancy in childhood, responsible for 15% of all pediatric cancer deaths. It is an heterogeneous disease that does not always respond to classical therapy; so the identification of new and specific molecular targets to improve existing therapy is needed. We have previously demonstrated the involvement of the Notch pathway in the onset and progression of neuroblastoma. In this study we further investigated the role of Notch signaling and identified Delta-like 1 (DLL1) as a novel molecular target in neuroblastoma cells with a high degree of MYCN amplification, which is a major oncogenic driver in neuroblastoma. The possibility to act on DLL1 expression levels by using microRNAs (miRNAs) was assessed.

Methods

DLL

SUBMITTER: Bettinsoli P 

PROVIDER: S-EPMC5438559 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature