Atorvastatin alters the expression of genes related to bile acid metabolism and circadian clock in livers of mice.

ABSTRACT:

Aim

Atorvastatin is a HMG-CoA reductase inhibitor used for hyperlipidemia. Atorvastatin is generally safe but may induce cholestasis. The present study aimed to examine the effects of atorvastatin on hepatic gene expression related to bile acid metabolism and homeostasis, as well as the expression of circadian clock genes in livers of mice.

Methods

Adult male mice were given atorvastatin (10, 30, and 100 mg/kg, po) daily for 30 days, and blood biochemistry, histopathology, and gene expression were examined.

Results

Repeated administration of atorvastatin did not affect animal body weight gain or liver weights. Serum enzyme activities were in the normal range. Histologically, the high dose of atorvastatin produced scattered swollen hepatocytes, foci of feathery-like de

SUBMITTER: Li WK 

PROVIDER: S-EPMC5438592 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature