Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study.

ABSTRACT:

Background and aims

This study aimed to access possible relationships between breast cancer subtypes and sites of distant metastasis in breast cancer.

Results

A total of 243,896 patients, including 226,451 cases in control groups were identified. Bone metastasis was found in 8848 cases, compared with 1,000 brain metastasis cases, 3434 liver metastasis cases and 4167 lung metastasis cases. Patients with all subtypes were most prone to bone metastases, the incidence of bone metastasis in HR+/HER2+ subtype was up to 5.1 %. Further, HR-/HER2+ subtype patients had a higher probability of brain (OR = 1.978) metastasis compared to HR+/HER2- subtype patients. In addition, liver metastasis was more frequently observed in the HER2 positive subtypes compared with HER2 negative subtypes

SUBMITTER: Wu Q 

PROVIDER: S-EPMC5438624 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature