Adipophilin as prognostic biomarker in clear cell renal cell carcinoma.

ABSTRACT:

Objective

To study the expression of adipophilin (PLIN2), a lipid storage-associated cell protein, in different subtypes of renal cell cancer and to elucidate its prognostic value.

Materials and methods

Two-hundred-seventy-five patients with renal cell carcinoma (RCC) were included in this study. Immunohistochemistry with a polyclonal antibody to adipophilin was used on the tissue microarray (formalin-fixed, paraffin-embedded tissue) for detection of adipophilin. Median follow-up time was 91 (range 1-159) months in the whole cohort and 100 (1-159) months for patients with clear-cell RCC. Additional validation for adipophilin was performed using publicly available gene expression data for clear cell RCC from The Cancer Genome Atlas (TCGA).

Results

Adipophilin expressio

SUBMITTER: Tolkach Y 

PROVIDER: S-EPMC5438682 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature