A recombinant fungal compound induces anti-proliferative and pro-apoptotic effects on colon cancer cells.

ABSTRACT: Finding intracellular pathways and molecules that can prevent the proliferation of colon cancer cells can provide significant bases for developing treatments for this disease. Ostreolysin (Oly) is a protein found in the mushroom Pleurotus ostreatus, and we have produced a recombinant version of this protein (rOly).We measured the viability of several colon cancer cells treated with rOly. Xenografts and syngeneic colon cancer cells were injected into in vivo mouse models, which were then treated with this recombinant protein.rOly treatment induced a significant reduction in viability of human and mouse colon cancer cells. In contrast, there was no reduction in the viability of normal epithelial cells from the small intestine. In the search for cellular targets of rOly, we showed that it enh

SUBMITTER: Nimri L 

PROVIDER: S-EPMC5438697 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature